How GlycoMAb works

GlycoMAb® works by genetically engineering the antibody-producing cells with a gene encoding an oligosaccharide-modifying enzyme. The modified cells produce new molecular variants of the antibody, bearing bisected non-fucosylated oligosaccharides. These special oligosaccharides are not made by the standard production cell lines.

Antibodies produced using GlycoMAb® are highly enriched in bisected non-fucosylated glycosylation variants. The modified antibodies bind with higher affinity to the human FcgRIIIa receptor on immune effector cells. Increased binding affinity for this receptor translates into more efficient killing of the antibody-targeted cells by the immmune effectors, a mechanism called antibody-dependent cellular cytotoxicity, or ADCC.