GlycArt Biotechnology

Camel and camelid antibodies, nanobodies by phage display

Key Choices

  • We offer a gaggle of miRNA Inhibitors for knockdown of over 5000 miRNAs from human, mouse, and rat.
  • Lentiviral provide for integration of genetic supplies into host cells, inflicting safe, long term gene expression.
  • Lentivirus has a broad host differ and may infect every dividing and non-dividing cells, allowing gene provide to every kind of cell types.

Background

Non-coding RNAs and significantly microRNAs have been discovered to behave as grasp regulators of most cancers initiation and improvement. The intention of our analysis was to seek out and characterize the carry out of however functionally uncharacterized microRNAs in human breast carcinogenesis.

miRNA inhibitors block miRNA regulation of purpose gene expression by safe suppression and may knock down native miRNA expression in cells. They are often utilized in miRNA loss-of-function analysis, miRNA purpose site identification and validation, and miRNA screening experiments. abm‘s Lentivirus miRNA Inhibitors allow for safe, long term expression of miRNA inhibitors out of your cell line.

For gene regulation and helpful analysis, abm presents a variety of expression strategies for:

  1. siRNA: successfully categorical any purpose siRNA to knockdown any gene with out the need to design hair-pin loop shRNA constructions, obtainable in lentivirus, AAV and Adenovirus.
  2. miRNA: inhibit or over-express any miRNA for analysis of post-transcriptional gene regulation in mammalian strategies using our ready-to-use viral vectors and packaged viruses, along with our detection and quantification devices.
  3. UTR Reporters: quantitatively analysis a specific miRNA’s regulation of its purpose gene using our 3’UTR or 5’UTR platform, all obtainable as a library of premade lentiviral vectors and lentiviruses for any human, mouse or rat gene.
abm hsa mirna inhibitor
abm hsa mirna inhibitor

Methods

In an unbiased technique, we utilized a longtime model system for breast most cancers (BC) stem cell formation (“mammosphere assay”) to determine full miRNome alterations in breast carcinogenesis. Medical samples of BC victims had been used to guage the human relevance of the newly acknowledged miRNA candidates. One promising candidate, miR-1287-5p, was further explored on its impression on quite a lot of hallmarks of most cancers. The molecular mode of movement was characterised by full transcriptome analysis, in silico prediction devices, miRNA-interaction assays, pheno-copy assays, and drug sensitivity assays.

hsa-let-7e miRNA Inhibitor

MIH01013 2 x 5.0 nmol
EUR 176

hsa-let-7g miRNA Inhibitor

MIH01020 2 x 5.0 nmol
EUR 176

hsa-let-7i miRNA Inhibitor

MIH01023 2 x 5.0 nmol
EUR 176

hsa-miR-1 miRNA Inhibitor

MIH01026 2 x 5.0 nmol
EUR 176

hsa-miR-100 miRNA Inhibitor

MIH01027 2 x 5.0 nmol
EUR 176

hsa-miR-101 miRNA Inhibitor

MIH01030 2 x 5.0 nmol
EUR 176

hsa-miR-103 miRNA Inhibitor

MIH01033 2 x 5.0 nmol
EUR 176

hsa-miR-103b miRNA Inhibitor

MIH01037 2 x 5.0 nmol
EUR 176

hsa-miR-105 miRNA Inhibitor

MIH01038 2 x 5.0 nmol
EUR 176

hsa-miR-106a miRNA Inhibitor

MIH01041 2 x 5.0 nmol
EUR 176

hsa-miR-106b miRNA Inhibitor

MIH01044 2 x 5.0 nmol
EUR 176

hsa-miR-107 miRNA Inhibitor

MIH01047 2 x 5.0 nmol
EUR 176

hsa-miR-10a miRNA Inhibitor

MIH01048 2 x 5.0 nmol
EUR 176

hsa-miR-10b miRNA Inhibitor

MIH01051 2 x 5.0 nmol
EUR 176

hsa-miR-1178 miRNA Inhibitor

MIH01054 2 x 5.0 nmol
EUR 176

hsa-miR-1179 miRNA Inhibitor

MIH01057 2 x 5.0 nmol
EUR 176

hsa-miR-1180 miRNA Inhibitor

MIH01058 2 x 5.0 nmol
EUR 176

hsa-miR-1181 miRNA Inhibitor

MIH01061 2 x 5.0 nmol
EUR 176

hsa-miR-1182 miRNA Inhibitor

MIH01062 2 x 5.0 nmol
EUR 176

hsa-miR-1183 miRNA Inhibitor

MIH01063 2 x 5.0 nmol
EUR 176

hsa-miR-1184 miRNA Inhibitor

MIH01064 2 x 5.0 nmol
EUR 176

hsa-miR-1185 miRNA Inhibitor

MIH01065 2 x 5.0 nmol
EUR 176

hsa-miR-1193 miRNA Inhibitor

MIH01069 2 x 5.0 nmol
EUR 176

hsa-miR-1197 miRNA Inhibitor

MIH01070 2 x 5.0 nmol
EUR 176

hsa-miR-1200 miRNA Inhibitor

MIH01073 2 x 5.0 nmol
EUR 176

hsa-miR-1201 miRNA Inhibitor

MIH01074 2 x 5.0 nmol
EUR 176

hsa-miR-1202 miRNA Inhibitor

MIH01075 2 x 5.0 nmol
EUR 176

hsa-miR-1203 miRNA Inhibitor

MIH01076 2 x 5.0 nmol
EUR 176

hsa-miR-1204 miRNA Inhibitor

MIH01077 2 x 5.0 nmol
EUR 176

hsa-miR-1205 miRNA Inhibitor

MIH01078 2 x 5.0 nmol
EUR 176

hsa-miR-1206 miRNA Inhibitor

MIH01079 2 x 5.0 nmol
EUR 176

hsa-miR-1208 miRNA Inhibitor

MIH01082 2 x 5.0 nmol
EUR 176

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