Calprotectin is an important calcium signaling protein involved in wound healing. A complex of MRP14 and MRP8, calprotectin plays a role in vascular inflammation and leukocyte recruitment. This 36 kDa complex is a calcium and zinc-binding protein that represents 60% of the cytosolic proteins of granulocytes. Classified as a marker of molecular pattern associated with damage, it shows protective antimicrobial properties.
The extracellular release of calprotectin during cell damage/stress can be used as a marker of intestinal inflammation. There is growing evidence that fecal calprotectin correlates with mucosal disease activity that can be used as a follow-up response to relapse and treatments in inflammatory bowel disease. Measurement of the calprotectin concentration in the stool is an indirect measure of the neutrophil infiltrate in the intestinal mucosa.
Abbr: Calprotectin, native (human)
Source: Human leukocytes
Applications: Determination of fecal calprotectin has been shown to be useful in the diagnosis and treatment of inflammatory bowel disease.
Molecular Weight: Heterotetramer containing two 8 kDa and two 14 kDa subunits
Purity: > 90% by SDS polyacrylamide electrophoresis, purified by conventional chromatography procedures
Synonyms: Protein S100; calgranulin; leukocyte complex L1; migration inhibitory factor related protein; MRP8 / 14; S100 calcium-binding protein